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TESK1
Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Probably plays a central role at and after the meiotic phase of spermatogenesis. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.12.1; Kinase, protein; LISK family; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; Protein kinase, dual-specificity (non-receptor); TESK subfamily; TKL group |
| Chromosomal Location of rat Ortholog: 5q22 |
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Cellular Component:
centrosome; cytoplasm; cytoplasmic vesicle; lamellipodium; nucleus; perinuclear region of cytoplasm
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Molecular Function:
ATP binding; metal ion binding; protein binding; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity
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Biological Process:
actin cytoskeleton organization; establishment of vesicle localization; negative regulation of cilium assembly; negative regulation of phosphorylation; negative regulation of protein autophosphorylation; negative regulation of protein serine/threonine kinase activity; podocyte cell migration; positive regulation of protein localization to nucleus; positive regulation of protein phosphorylation; positive regulation of stress fiber assembly; positive regulation of substrate adhesion-dependent cell spreading; protein phosphorylation; regulation of actin cytoskeleton organization; regulation of protein localization; spermatogenesis
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Reference #:
Q63572
(UniProtKB)
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Alt. Names/Synonyms: Dual specificity testis-specific protein kinase 1; Tesk1; Testicular protein kinase 1; testis specific protein kinase 1; testis-specific kinase 1
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Gene Symbols: Tesk1
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Molecular weight:
67,988 Da
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Basal Isoelectric point:
8.27
Predict pI for various phosphorylation states
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CST Pathways:
Microtubule Dynamics
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