TESK1 a TKL kinase of the LISK fanily. Its testicular germ cell-specific expression and developmental pattern of expression in the mouse suggests that this kinase plays an important role at and after the meiotic phase of spermatogenesis. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.12.1; Kinase, protein; LISK family; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TESK subfamily; TKL group
Chromosomal Location of Human Ortholog: 5q22
Cellular Component:  cytoplasm; nucleus
Molecular Function:  ATP binding; metal ion binding; protein C-terminus binding; protein kinase binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity
Biological Process:  actin cytoskeleton organization; negative regulation of protein autophosphorylation; negative regulation of protein serine/threonine kinase activity; peptidyl-tyrosine phosphorylation; positive regulation of stress fiber assembly; regulation of protein localization; spermatogenesis
Reference #:  Q63572 (UniProtKB)
Alt. Names/Synonyms: Dual specificity testis-specific protein kinase 1; Tesk1; Testicular protein kinase 1; testis specific protein kinase 1; testis-specific kinase 1
Gene Symbols: Tesk1
Molecular weight: 67,988 Da
Basal Isoelectric point: 8.27  Predict pI for various phosphorylation states
CST Pathways:  Microtubule Dynamics
Select Structure to View Below

TESK1

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene