Lasp-1 Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 10q31
Cellular Component:  cortical actin cytoskeleton; cytoplasm; focal adhesion
Molecular Function:  actin filament binding; ion transmembrane transporter activity; metal ion binding
Biological Process:  ion transmembrane transport; ion transport
Reference #:  Q99MZ8 (UniProtKB)
Alt. Names/Synonyms: LASP-1; Lasp1; LIM and SH3 domain protein 1; LIM and SH3 protein 1
Gene Symbols: Lasp1
Molecular weight: 29,970 Da
Basal Isoelectric point: 6.61  Predict pI for various phosphorylation states
Select Structure to View Below

Lasp-1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene