LSM2 Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. Belongs to the snRNP Sm proteins family. Note: This description may include information from UniProtKB.
Protein type: RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of Human Ortholog: 17 B1|17 18.52 cM
Cellular Component:  catalytic step 2 spliceosome; cytoplasm; Lsm1-7-Pat1 complex; Lsm2-8 complex; nucleus; P-body; spliceosomal complex; U2-type precatalytic spliceosome; U4/U6 x U5 tri-snRNP complex; U6 snRNP
Molecular Function:  protein binding; protein kinase binding; Ral GTPase binding
Biological Process:  mRNA catabolic process; mRNA processing; mRNA splicing, via spliceosome; RNA splicing; spliceosomal tri-snRNP complex assembly
Reference #:  O35900 (UniProtKB)
Alt. Names/Synonyms: D17H6S56E; D17H6S56E-; D17H6S56E-2; D17H6S56E2; DM associated protein-like; Dmapl; Dmp; Dmpkap; dystrophia myotonica-protein kinase associated protein; G7b; G7b alternative form; Lsm2; LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated; LSM2 homolog, U6 small nuclear RNA associated; LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae); MGC13889; Protein G7b; Sm-X; Sm-X5; small ribonuclear protein G7b; SmX; SmX5; snRNP; snRNP core protein SMX5; snRNP core Sm-like protein Sm-x5; U6 snRNA-associated Sm-like protein LSm2
Gene Symbols: Lsm2
Molecular weight: 10,835 Da
Basal Isoelectric point: 6.05  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene