ID3 Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Expressed abundantly in lung, kidney and adrenal gland, but not in adult brain. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 5q36
Cellular Component:  cytoplasm; nucleus
Molecular Function:  bHLH transcription factor binding; DNA-binding transcription factor activity; leptomycin B binding; protein dimerization activity; protein domain specific binding; RNA polymerase II transcription factor binding; transcription factor binding
Biological Process:  cellular response to leptomycin B; central nervous system development; circadian rhythm; epithelial cell differentiation; heart development; metanephros development; muscle organ development; negative regulation of cell differentiation; negative regulation of DNA binding; negative regulation of DNA-binding transcription factor activity; negative regulation of gene expression; negative regulation of myoblast differentiation; negative regulation of neuron differentiation; negative regulation of osteoblast differentiation; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; neuron differentiation; notochord development; odontogenesis; positive regulation of apoptotic process; positive regulation of cell proliferation; regulation of cell cycle; regulation of DNA replication; response to wounding; transcription, DNA-templated
Reference #:  P41138 (UniProtKB)
Alt. Names/Synonyms: DNA-binding protein inhibitor ID-3; Id-3; Id3; Inhibitor of DNA binding 3; Inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
Gene Symbols: Id3
Molecular weight: 13,059 Da
Basal Isoelectric point: 5.88  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene