ITPKA Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.[provided by RefSeq, Apr 2011]
Protein type: Carbohydrate Metabolism - inositol phosphate; EC; Kinase, lipid; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2|2 E5
Cellular Component:  dendritic spine
Molecular Function:  ATP binding; calmodulin binding; calmodulin-dependent protein kinase activity; inositol-1,4,5-trisphosphate 3-kinase activity; kinase activity; nucleotide binding; Rac GTPase binding; transferase activity
Biological Process:  actin cytoskeleton organization; dendritic spine maintenance; inositol metabolic process; inositol phosphate biosynthetic process; phosphorylation; positive regulation of dendritic spine morphogenesis; regulation of synaptic plasticity
Reference #:  Q8R071 (UniProtKB)
Alt. Names/Synonyms: Inositol 1,4,5-trisphosphate 3-kinase A; Inositol-trisphosphate 3-kinase A; InsP 3-kinase A; IP3 3-kinase A; IP3-kinase A; IP3K A; IP3KA; Itpka; MGC28924; OTTMUSP00000017671
Gene Symbols: Itpka
Molecular weight: 50,935 Da
Basal Isoelectric point: 7.64  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene