ITPKA Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.[provided by RefSeq, Apr 2011]

Protein type: Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.127; Kinase, lipid; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2|2 E5

Cellular Component: dendritic spine

Molecular Function: ATP binding; calmodulin binding; calmodulin-dependent protein kinase activity; inositol-1,4,5-trisphosphate 3-kinase activity; kinase activity; nucleotide binding; Rac GTPase binding; transferase activity

Biological Process: actin cytoskeleton organization; dendritic spine maintenance; inositol metabolic process; inositol phosphate biosynthetic process; phosphorylation; positive regulation of dendritic spine morphogenesis; regulation of synaptic plasticity

Reference #: Q8R071 (UniProtKB)

Alt. Names/Synonyms: Inositol 1,4,5-trisphosphate 3-kinase A; Inositol-trisphosphate 3-kinase A; InsP 3-kinase A; IP3 3-kinase A; IP3-kinase A; IP3K A; IP3KA; Itpka; MGC28924; OTTMUSP00000017671

Gene Symbols: Itpka

Molecular weight: 50,935 Da

Basal Isoelectric point: 7.64 Predict pI for various phosphorylation states

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ITPKA

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