ITIH1 May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes. Contains a potential peptide which could stimulate a broad spectrum of phagocytotic cells. Belongs to the ITIH family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Inhibitor; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 14|14 B
Cellular Component:  extracellular matrix; extracellular region
Molecular Function:  peptidase inhibitor activity; protein binding; serine-type endopeptidase inhibitor activity
Biological Process:  extracellular matrix organization; hyaluronan metabolic process; negative regulation of peptidase activity
Reference #:  Q61702 (UniProtKB)
Alt. Names/Synonyms: inter-alpha (globulin) inhibitor, H1 polypeptide; inter-alpha trypsin inhibitor, heavy chain 1; Inter-alpha-inhibitor heavy chain 1; Inter-alpha-trypsin inhibitor heavy chain H1; Intin1; ITI heavy chain H1; ITI-HC1; Itih; Itih-1; Itih1
Gene Symbols: Itih1
Molecular weight: 101,067 Da
Basal Isoelectric point: 6.49  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene