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ITIH1
May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes. Contains a potential peptide which could stimulate a broad spectrum of phagocytotic cells. Belongs to the ITIH family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Inhibitor; Secreted; Secreted, signal peptide |
| Chromosomal Location of Human Ortholog: 14|14 B |
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Cellular Component:
extracellular matrix; extracellular region
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Molecular Function:
peptidase inhibitor activity; protein binding; serine-type endopeptidase inhibitor activity
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Biological Process:
extracellular matrix organization; hyaluronan metabolic process; negative regulation of peptidase activity
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Reference #:
Q61702
(UniProtKB)
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Alt. Names/Synonyms: inter-alpha (globulin) inhibitor, H1 polypeptide; inter-alpha trypsin inhibitor, heavy chain 1; Inter-alpha-inhibitor heavy chain 1; Inter-alpha-trypsin inhibitor heavy chain H1; Intin1; ITI heavy chain H1; ITI-HC1; Itih; Itih-1; Itih1
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Gene Symbols: Itih1
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Molecular weight:
101,067 Da
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Basal Isoelectric point:
6.49
Predict pI for various phosphorylation states
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