IRAP Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain. Belongs to the peptidase M1 family. Highly expressed in placenta, heart, kidney and small intestine. Detected at lower levels in neuronal cells in the brain, in skeletal muscle, spleen, liver, testes and colon. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Membrane protein, integral; Protease
Chromosomal Location of Human Ortholog: 17|17 A3.2
Cellular Component:  cytoplasm; cytoplasmic vesicle membrane; integral component of membrane; integral component of plasma membrane; membrane; perinuclear region of cytoplasm; plasma membrane
Molecular Function:  aminopeptidase activity; hydrolase activity; metal ion binding; metalloaminopeptidase activity; metallopeptidase activity; peptidase activity; peptide binding; protein binding; zinc ion binding
Biological Process:  negative regulation of cold-induced thermogenesis; peptide catabolic process; protein catabolic process; proteolysis; SMAD protein signal transduction
Reference #:  Q8C129 (UniProtKB)
Alt. Names/Synonyms: 2010309L07Rik; 4732490P18Rik; CAP; Cystinyl aminopeptidase; gp16; gp160; IRAP; LCAP; Leucyl-cystinyl aminopeptidase; leucyl/cystinyl aminopeptidase; Lnpep; OTase; Oxytocinase; PLAP; RP23-282E10.1; vp1; vp165
Gene Symbols: Lnpep
Molecular weight: 117,304 Da
Basal Isoelectric point: 5.62  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene