HePTP Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction. Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. Expressed exclusively in thymus and spleen. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor)
Chromosomal Location of mouse Ortholog: 1|1 E4
Cellular Component:  cytoplasm; cytoplasmic side of plasma membrane; cytoskeleton; cytosol
Molecular Function:  hydrolase activity; phosphatase activity; phosphoprotein phosphatase activity; protein tyrosine phosphatase activity
Biological Process:  dephosphorylation; protein dephosphorylation
Reference #:  Q8BUM3 (UniProtKB)
Alt. Names/Synonyms: BPTP; BPTP-4; C920001D21Rik; Hematopoietic protein-tyrosine phosphatase; HEPTP; LC-; LC-PTP; LPTP; MGC107411; protein tyrosine phosphatase, non-receptor type 7; PTN7; Ptpn7; Tyrosine-protein phosphatase non-receptor type 7
Gene Symbols: Ptpn7
Molecular weight: 40,351 Da
Basal Isoelectric point: 6.24  Predict pI for various phosphorylation states
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HePTP

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene