HIR Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ4 subfamily. Heart, skeletal muscle, and several different brain regions including the hippocampus. Note: This description may include information from UniProtKB.
Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 15 E1|15 37.74 cM
Cellular Component:  basolateral plasma membrane; cell junction; cytoplasmic vesicle; dendrite; integral component of membrane; membrane; neuronal cell body; plasma membrane; postsynaptic membrane; synapse
Molecular Function:  inward rectifier potassium channel activity; PDZ domain binding; voltage-gated ion channel activity
Biological Process:  ion transport; potassium ion import across plasma membrane; potassium ion transport; regulation of ion transmembrane transport
Reference #:  P52189 (UniProtKB)
Alt. Names/Synonyms: HIR; Inward rectifier K(+) channel Kir2.3; Inward rectifier potassium channel 4; IRK-3; Irk3; IRK4; Kcnf2; Kcnj4; Kir 2.3; MB-IRK3; Potassium channel, inwardly rectifying subfamily J member 4; potassium inwardly-rectifying channel, subfamily J, member 4
Gene Symbols: Kcnj4
Molecular weight: 49,899 Da
Basal Isoelectric point: 5.82  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene