GFAT2 Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Highest levels of expression in heart, placenta, and spinal cord. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - alanine, aspartate and glutamate; Carbohydrate Metabolism - amino sugar and nucleotide sugar; EC; Transferase
Chromosomal Location of mouse Ortholog: 11 B1.2|11 29.9 cM
Cellular Component: 
Molecular Function:  carbohydrate derivative binding; glutamine-fructose-6-phosphate transaminase (isomerizing) activity; transaminase activity; transferase activity
Biological Process:  carbohydrate derivative biosynthetic process; carbohydrate derivative metabolic process; cellular response to leukemia inhibitory factor; fructose 6-phosphate metabolic process; glutamine metabolic process; protein N-linked glycosylation; UDP-N-acetylglucosamine metabolic process
Reference #:  Q9Z2Z9 (UniProtKB)
Alt. Names/Synonyms: AI480523; D-fructose-6-phosphate amidotransferase 2; GFAT; GFAT 2; GFAT2; Gfpt2; Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2; glutamine fructose-6-phosphate transaminase 2; Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2; Glutamine:fructose 6 phosphate amidotransferase 2; Glutamine:fructose-6-phosphate amidotransferase 2; Hexosephosphate aminotransferase 2; OTTMUSP00000005729
Gene Symbols: Gfpt2
Molecular weight: 77,009 Da
Basal Isoelectric point: 6.72  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein