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GFAT2
Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Highest levels of expression in heart, placenta, and spinal cord. Note: This description may include information from UniProtKB.
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| Protein type: Amino Acid Metabolism - alanine, aspartate and glutamate; Carbohydrate Metabolism - amino sugar and nucleotide sugar; EC 2.6.1.16; Transferase |
| Chromosomal Location of Human Ortholog: 11 B1.2|11 29.9 cM |
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Cellular Component:
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Molecular Function:
carbohydrate derivative binding; glutamine-fructose-6-phosphate transaminase (isomerizing) activity; transaminase activity; transferase activity
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Biological Process:
carbohydrate derivative biosynthetic process; carbohydrate derivative metabolic process; cellular response to leukemia inhibitory factor; fructose 6-phosphate metabolic process; glutamine metabolic process; protein N-linked glycosylation; UDP-N-acetylglucosamine metabolic process
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Reference #:
Q9Z2Z9
(UniProtKB)
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Alt. Names/Synonyms: AI480523; D-fructose-6-phosphate amidotransferase 2; GFAT 2; GFAT2; Gfpt2; Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2; glutamine fructose-6-phosphate transaminase 2; Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2; Glutamine:fructose 6 phosphate amidotransferase 2; Hexosephosphate aminotransferase 2; OTTMUSP00000005729
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Gene Symbols: Gfpt2
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Molecular weight:
77,009 Da
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Basal Isoelectric point:
6.72
Predict pI for various phosphorylation states
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