GRB14 Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal. Belongs to the GRB7/10/14 family. Expressed at high levels in the liver, kidney, pancreas, testis, ovary, heart and skeletal muscle. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 2|2 C1.3
Cellular Component:  cytoplasm; endosome; Golgi apparatus; intracellular membrane-bounded organelle; membrane; plasma membrane
Molecular Function:  identical protein binding; phosphoprotein binding; protein binding; protein homodimerization activity; receptor tyrosine kinase binding; SH3/SH2 adaptor activity
Biological Process:  cellular response to insulin stimulus; insulin receptor signaling pathway; negative regulation of insulin receptor signaling pathway; negative regulation of meiotic cell cycle process involved in oocyte maturation; signal transduction
Reference #:  Q9JLM9 (UniProtKB)
Alt. Names/Synonyms: AI505286; Grb14; GRB14 adapter protein; growth factor receptor bound protein 14; Growth factor receptor-bound protein 14; OTTMUSP00000013796; RP23-308K19.2
Gene Symbols: Grb14
Molecular weight: 60,573 Da
Basal Isoelectric point: 8.69  Predict pI for various phosphorylation states
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GRB14

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein