|
GRB14
Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal. Belongs to the GRB7/10/14 family. Expressed at high levels in the liver, kidney, pancreas, testis, ovary, heart and skeletal muscle. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Adaptor/scaffold |
| Chromosomal Location of Human Ortholog: 2|2 C1.3 |
|
Cellular Component:
cytoplasm; endosome; Golgi apparatus; intracellular membrane-bounded organelle; membrane; plasma membrane
|
|
Molecular Function:
identical protein binding; phosphoprotein binding; protein binding; protein homodimerization activity; receptor tyrosine kinase binding; SH3/SH2 adaptor activity
|
|
Biological Process:
cellular response to insulin stimulus; insulin receptor signaling pathway; negative regulation of insulin receptor signaling pathway; negative regulation of meiotic cell cycle process involved in oocyte maturation; signal transduction
|
|
Reference #:
Q9JLM9
(UniProtKB)
|
|
Alt. Names/Synonyms: AI505286; Grb14; GRB14 adapter protein; growth factor receptor bound protein 14; Growth factor receptor-bound protein 14; OTTMUSP00000013796; RP23-308K19.2
|
|
Gene Symbols: Grb14
|
|
Molecular weight:
60,573 Da
|
|
Basal Isoelectric point:
8.69
Predict pI for various phosphorylation states
|
