GRB7 Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress. Belongs to the GRB7/10/14 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of human Ortholog: 17q12
Cellular Component:  cell projection; cytoplasmic stress granule; cytosol; focal adhesion; plasma membrane
Molecular Function:  identical protein binding; phosphatidylinositol binding; protein binding; protein kinase binding; RNA binding; SH3/SH2 adaptor activity
Biological Process:  axon guidance; epidermal growth factor receptor signaling pathway; ERBB2 signaling pathway; leukocyte migration; negative regulation of translation; positive regulation of cell migration; positive regulation of signal transduction; stress granule assembly
Reference #:  Q14451 (UniProtKB)
Alt. Names/Synonyms: B47; Epidermal growth factor receptor GRB-7; GRB7; GRB7 adapter protein; growth factor receptor bound protein 7; Growth factor receptor-bound protein 7
Gene Symbols: GRB7
Molecular weight: 59,681 Da
Basal Isoelectric point: 8.82  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein