4E-BP1 Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. Belongs to the eIF4E-binding protein family. Note: This description may include information from UniProtKB.
Protein type: Translation; Translation initiation
Chromosomal Location of Human Ortholog: 8 A2|8 15.95 cM
Cellular Component:  cytoplasm; cytosol; glutamatergic synapse; nucleus; postsynaptic cytosol; protein-containing complex
Molecular Function:  eukaryotic initiation factor 4E binding; protein binding; protein phosphatase 2A binding; translation initiation factor binding; translation repressor activity
Biological Process:  cellular response to dexamethasone stimulus; cellular response to hypoxia; G1/S transition of mitotic cell cycle; insulin receptor signaling pathway; IRES-dependent translational initiation of linear mRNA; negative regulation of protein complex assembly; negative regulation of translation; negative regulation of translational initiation; positive regulation of mitotic cell cycle; regulation of translation; regulation of translational initiation; response to amino acid starvation; TOR signaling
Reference #:  Q60876 (UniProtKB)
Alt. Names/Synonyms: 4E-BP1; 4EBP1; AA959816; eIF4E-binding protein 1; Eif4ebp1; eukaryotic translation initiation factor 4E binding protein 1; Eukaryotic translation initiation factor 4E-binding protein 1; PHAS-I; Phosphorylated heat- and acid-stable protein regulated by insulin 1
Gene Symbols: Eif4ebp1
Molecular weight: 12,325 Da
Basal Isoelectric point: 5.01  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  Angiogenesis  |  Insulin Receptor Signaling  |  mTOR Signaling  |  PI3K/Akt Signaling  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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4E-BP1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene