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Ets-1
Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion. Belongs to the ETS family. Highly expressed within lymphoid cells. Isoforms c-ETS-1A and Ets-1 p27 are both detected in all fetal tissues tested, but vary with tissue type in adult tissues. None is detected in brain or kidney. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor |
| Chromosomal Location of rat Ortholog: 8q21 |
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Cellular Component:
cytoplasm; nucleoplasm; nucleus; transcription regulator complex
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Molecular Function:
DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; histone acetyltransferase binding; identical protein binding; nuclear receptor coactivator activity; nucleic acid binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding; transcription corepressor binding
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Biological Process:
angiogenesis involved in wound healing; cell differentiation; cell motility; cellular response to hydrogen peroxide; estrous cycle; female pregnancy; hypothalamus development; immune system process; negative regulation of cell cycle; negative regulation of inflammatory response; pituitary gland development; PML body organization; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of DNA-templated transcription; positive regulation of endothelial cell migration; positive regulation of erythrocyte differentiation; positive regulation of gene expression; positive regulation of inflammatory response; positive regulation of leukocyte adhesion to vascular endothelial cell; positive regulation of miRNA transcription; positive regulation of transcription by RNA polymerase II; regulation of angiogenesis; regulation of apoptotic process; regulation of extracellular matrix disassembly; regulation of transcription by RNA polymerase II; response to antibiotic; response to estradiol; response to hypoxia; response to interleukin-1; response to laminar fluid shear stress; response to mechanical stimulus; response to salt; transcription by RNA polymerase II
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Reference #:
P41156
(UniProtKB)
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Alt. Names/Synonyms: Ets avian erythroblastosis virus E2 oncogene homolog 1 (tumor progression locus 1); Ets-1; Ets1; Etsoncb; MGC124638; p54; Protein C-ets-1; Tpl1; v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
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Gene Symbols: Ets1
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Molecular weight:
50,423 Da
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Basal Isoelectric point:
5.05
Predict pI for various phosphorylation states
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CST Pathways:
B Cell Receptor Signaling
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Growth And Differentiation Control by MAPKs
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Regulation of P38 MAPKs
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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