CCNE1 Essential for the control of the cell cycle at the G1/S (start) transition. Belongs to the cyclin family. Cyclin E subfamily. Highly expressed in testis and placenta. Low levels in bronchial epithelial cells. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Activator; Cell cycle regulation; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 1q21
Cellular Component:  centrosome; cyclin E1-CDK2 complex; cyclin-dependent protein kinase holoenzyme complex; cytoplasm; nucleoplasm; nucleus
Molecular Function:  cyclin-dependent protein serine/threonine kinase regulator activity; kinase activity; protein binding; protein kinase binding; protein-containing complex binding
Biological Process:  animal organ regeneration; antral ovarian follicle growth; cell division; cellular response to nutrient; chromosome organization involved in meiotic cell cycle; DNA replication initiation; G1/S transition of mitotic cell cycle; liver development; mitotic cell cycle phase transition; negative regulation of transcription by RNA polymerase II; positive regulation of cell differentiation; positive regulation of G1/S transition of mitotic cell cycle; protein phosphorylation; regulation of cell cycle; regulation of cellular protein localization; regulation of cyclin-dependent protein serine/threonine kinase activity; response to corticosterone; response to cytokine; response to drug; response to estradiol; response to ethanol; response to methylmercury; response to organic cyclic compound; response to organonitrogen compound; response to progesterone; response to purine-containing compound; response to steroid hormone; response to vitamin E; synapsis; telomere maintenance; Wnt signaling pathway
Reference #:  P39949 (UniProtKB)
Alt. Names/Synonyms: Ccne; CYCLE; cyclin E1; G1/S-specific cyclin-E1
Gene Symbols: Ccne1
Molecular weight: 47,482 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  Pfam  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA