a widely expressed, sequence-specific DNA-binding transcriptional regulator, insulator, and organizer of higher-order chromatin structure. Acts as a tumor suppressor. Contains 11 C2H2-type zinc fingers. Involved in promoter activation or repression, hormone-responsive gene silencing, methylation-dependent chromatin insulation, and genomic imprinting. Mediates pairing between X chromosomes and interactions between distant regulatory elements. Binds to promoters of c-myc, PLK, PIM1 and APP. A critical regulator of cell-cycle arrest and death after B cell receptor signaling in immature B cells. CTCF, together with YY1 and Tsix, form a regulated epigenetic switch for X-inactivation. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; Transcription factor; Tumor suppressor
Molecular Function: chromatin binding; chromatin insulator sequence binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; metal ion binding; RNA polymerase II proximal promoter sequence-specific DNA binding; sequence-specific DNA binding; transcription regulatory region DNA binding
Biological Process: chromatin organization; chromosome segregation; DNA methylation; maintenance of DNA methylation; negative regulation of cell proliferation; negative regulation of gene expression; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; nucleosome positioning; positive regulation of gene expression; positive regulation of pri-miRNA transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; protein localization to chromosome, centromeric region; regulation of gene expression by genetic imprinting; regulation of gene expression, epigenetic; regulation of histone acetylation; regulation of histone methylation; regulation of molecular function, epigenetic; regulation of transcription, DNA-templated