C3 C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. In chronic inflammation, acts as a chemoattractant for neutrophils. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C3-beta-c: Acts as a chemoattractant for neutrophils in chronic inflammation. Acylation stimulating protein: adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for C5AR2. Promotes the phosphorylation, ARRB2-mediated internalization and recycling of C5AR2. Plasma. The acylation stimulating protein (ASP) is expressed in adipocytes and released into the plasma during both the fasting and postprandial periods. Note: This description may include information from UniProtKB.
Protein type: Inhibitor; Secreted; Secreted, signal peptide
Chromosomal Location of mouse Ortholog: 17 D|17 29.72 cM
Cellular Component:  cell surface; extracellular region; extracellular space; plasma membrane; protein-containing complex; serine-type endopeptidase complex
Molecular Function:  C5L2 anaphylatoxin chemotactic receptor binding; endopeptidase inhibitor activity; lipid binding; protein binding
Biological Process:  amyloid-beta clearance; cell surface receptor signaling pathway involved in cell-cell signaling; complement activation; complement activation, alternative pathway; complement activation, classical pathway; complement-dependent cytotoxicity; complement-mediated synapse pruning; fatty acid metabolic process; immune system process; inflammatory response; innate immune response; lipid metabolic process; neuron remodeling; opsonization; oviduct epithelium development; positive regulation of activation of membrane attack complex; positive regulation of angiogenesis; positive regulation of apoptotic cell clearance; positive regulation of apoptotic process in another organism; positive regulation of developmental growth; positive regulation of ERK1 and ERK2 cascade; positive regulation of G protein-coupled receptor signaling pathway; positive regulation of glucose transmembrane transport; positive regulation of immune response; positive regulation of lipid storage; positive regulation of opsonization; positive regulation of phagocytosis; positive regulation of phagocytosis, engulfment; positive regulation of protein phosphorylation; positive regulation of receptor-mediated endocytosis; positive regulation of type IIa hypersensitivity; positive regulation of vascular endothelial growth factor production; proteolysis; regulation of complement activation; regulation of complement activation, alternative pathway; regulation of triglyceride biosynthetic process; response to bacterium; retina development in camera-type eye; vascular associated smooth muscle cell differentiation; vertebrate eye-specific patterning
Reference #:  P01027 (UniProtKB)
Alt. Names/Synonyms: acylation stimulating protein; AI255234; ASP; C3; C3-beta-c; C3a anaphylatoxin; C3adesArg; C3bc; CO3; Complement C3; Complement C3 alpha chain; Complement C3 beta chain; Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3c alpha' chain fragment 2; Complement C3d fragment; Complement C3dg fragment; Complement C3f fragment; Complement C3g fragment; complement component 3; complement component 3d; complement factor 3; HSE-MSF; Plp
Gene Symbols: C3
Molecular weight: 186,484 Da
Basal Isoelectric point: 6.29  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene