CAD This protein is a fusion protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase). In the central section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - alanine, aspartate and glutamate; EC 2.1.3.2; EC 3.5.2.3; EC 6.3.5.5; Hydrolase; Ligase; Nucleotide Metabolism - pyrimidine; Transferase
Chromosomal Location of Human Ortholog: 5|5 B1
Cellular Component:  cell projection; cytoplasm; cytosol; neuronal cell body; nuclear matrix; nucleoplasm; nucleus; protein-containing complex; terminal bouton
Molecular Function:  amino acid binding; aspartate carbamoyltransferase activity; ATP binding; carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; carboxyl- or carbamoyltransferase activity; catalytic activity; dihydroorotase activity; enzyme binding; hydrolase activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides; identical protein binding; ligase activity; metal ion binding; nucleotide binding; protein kinase activity; transferase activity; UTP binding; zinc ion binding
Biological Process:  'de novo' pyrimidine nucleobase biosynthetic process; cellular amino acid metabolic process; citrulline biosynthetic process; drug metabolic process; glutamine metabolic process; metabolic process; nitrogen compound metabolic process; peptidyl-threonine phosphorylation; protein autophosphorylation; pyrimidine nucleotide biosynthetic process; response to insulin; response to starvation; UTP biosynthetic process
Reference #:  B2RQC6 (UniProtKB)
Alt. Names/Synonyms: 2410008J01Rik; Aspartate carbamoyltransferase; AU018859; Cad; CAD protein; carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; Cpad; Dihydroorotase; Glutamine-dependent carbamoyl-phosphate synthase; OTTMUSP00000025444; PYR1
Gene Symbols: Cad
Molecular weight: 243,238 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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CAD

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene