BIK Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Membrane protein, integral; Mitochondrial
Chromosomal Location of Human Ortholog: 15|15 E1
Cellular Component:  integral component of membrane; membrane; mitochondrial envelope; mitochondrion
Molecular Function:  BH domain binding; protein binding; protein heterodimerization activity
Biological Process:  apoptotic mitochondrial changes; apoptotic process; male gonad development; positive regulation of protein homooligomerization; positive regulation of release of cytochrome c from mitochondria; spermatogenesis
Reference #:  O70337 (UniProtKB)
Alt. Names/Synonyms: Bcl-2-interacting killer; BCL2-interacting killer; Bcl2-interacting killer-like; Bik; Bik protein; Biklk; Blk; Nbk
Gene Symbols: Bik
Molecular weight: 16,901 Da
Basal Isoelectric point: 7.76  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein