ANPB a transmembrane guanylyl cyclase enzyme with a tyrosine kinse domain. Receptor for natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Contains five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. Is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Multiple mutations linked to acromesomelic dysplasia (skeletal malformation). 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 4.6.1.2; Guanylyl cyclase; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity (receptor); RGC family; RGC group; Receptor, misc.
Chromosomal Location of Human Ortholog: 4 A5|4 23.05 cM
Cellular Component:  integral component of membrane; integral component of plasma membrane; membrane; plasma membrane
Molecular Function:  ATP binding; GTP binding; guanylate cyclase activity; hormone binding; identical protein binding; lyase activity; natriuretic peptide receptor activity; nucleotide binding; peptide hormone binding; peptide receptor activity; phosphorus-oxygen lyase activity; protein kinase activity
Biological Process:  bone development; cGMP biosynthetic process; cGMP-mediated signaling; cyclic nucleotide biosynthetic process; intracellular signal transduction; negative regulation of meiotic cell cycle; negative regulation of oocyte maturation; ossification; positive regulation of cGMP-mediated signaling; protein phosphorylation; receptor guanylyl cyclase signaling pathway; reproductive process; signal transduction
Reference #:  Q6VVW5 (UniProtKB)
Alt. Names/Synonyms: ANP-B; ANPR-B; ANPRB; Atrial natriuretic peptide receptor 2; Atrial natriuretic peptide receptor type B; cn; GC-B; GC-B2; GC-B3; Guanylate cyclase B; guanylyl cyclase-B; mNPR-B; natriuretic peptide receptor 2; natriuretic peptide receptor B type; Nppb receptor; NPR-B; Npr2; OTTMUSP00000007443
Gene Symbols: Npr2
Molecular weight: 117,060 Da
Basal Isoelectric point: 6.41  Predict pI for various phosphorylation states
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ANPB

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene