ANKRD13 Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 5|5 F
Cellular Component:  cytoplasm; endosome; late endosome; membrane; perinuclear region of cytoplasm; plasma membrane
Molecular Function:  ubiquitin-dependent protein binding
Biological Process:  negative regulation of protein localization to endosome; negative regulation of receptor internalization
Reference #:  Q80UP5 (UniProtKB)
Alt. Names/Synonyms: 1100001D10Rik; AN13A; Ankrd13; Ankrd13a; ankyrin repeat domain 13a; Ankyrin repeat domain-containing protein 13A; AU046136; MGC118502; OTTMUSP00000015490
Gene Symbols: Ankrd13a
Molecular weight: 67,177 Da
Basal Isoelectric point: 4.99  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene