ANKRD13
Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. Note: This description may include information from UniProtKB.
|
Protein type: Unknown function |
Chromosomal Location of mouse Ortholog: 5|5 F |
Cellular Component:
cytoplasm; endosome; late endosome; membrane; perinuclear region of cytoplasm; plasma membrane
|
Molecular Function:
ubiquitin-dependent protein binding
|
Biological Process:
negative regulation of protein localization to endosome; negative regulation of receptor internalization
|
Reference #:
Q80UP5
(UniProtKB)
|
Alt. Names/Synonyms: 1100001D10Rik; AN13A; Ankrd13; Ankrd13a; ankyrin repeat domain 13a; Ankyrin repeat domain-containing protein 13A; AU046136; MGC118502; OTTMUSP00000015490
|
Gene Symbols: Ankrd13a
|
Molecular weight:
67,177 Da
|
Basal Isoelectric point:
4.99
Predict pI for various phosphorylation states
|