|
AMPKB2
Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). Belongs to the 5'-AMP-activated protein kinase beta subunit family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Autophagy; Protein kinase, regulatory subunit |
| Chromosomal Location of mouse Ortholog: 3|3 F2.2 |
|
Cellular Component:
apical plasma membrane; cAMP-dependent protein kinase complex; cytoplasm; cytosol; nucleoplasm; nucleotide-activated protein kinase complex; nucleus
|
|
Molecular Function:
AMP-activated protein kinase activity; enzyme binding; protein kinase binding
|
|
Biological Process:
cellular response to nutrient levels; fatty acid biosynthetic process; fatty acid metabolic process; lipid metabolic process; positive regulation of cold-induced thermogenesis; signal transduction
|
|
Reference #:
Q6PAM0
(UniProtKB)
|
|
Alt. Names/Synonyms: 5'-AMP-activated protein kinase subunit beta-2; 5730553K21Rik; AAKB2; AMPK subunit beta-2; AMPKB2; AW049591; BB124140; Prkab2; protein kinase, AMP-activated, beta 2 non-catalytic subunit
|
|
Gene Symbols: Prkab2
|
|
Molecular weight:
30,209 Da
|
|
Basal Isoelectric point:
5.99
Predict pI for various phosphorylation states
|
|
CST Pathways:
AMPK Signaling
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
