Destrin Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner. Belongs to the actin-binding proteins ADF family. Widely distributed in various tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 3q41
Cellular Component:  actin cytoskeleton; cortical actin cytoskeleton; cytoplasm
Molecular Function:  actin filament binding
Biological Process:  actin filament depolymerization; actin filament fragmentation; actin filament severing; positive regulation of actin filament depolymerization
Reference #:  Q7M0E3 (UniProtKB)
Alt. Names/Synonyms: Actin-depolymerizing factor; ADF; DEST; Destrin; Dstn
Gene Symbols: Dstn
Molecular weight: 18,534 Da
Basal Isoelectric point: 8.19  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene