Destrin an actin-depolymerizing cytoskeletal protein that belongs to the ADF actin-binding protein family. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Present in many vertebrate tissues and particularly abundant in neuronal cells. It binds F-actin in a pH-dependent manner which affects it's severing/depolymerizing activities. It also binds G-actin at pH 8.0 thereby sequestering monomers and preventing polymerization. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 3q41
Cellular Component:  actin cytoskeleton; cortical actin cytoskeleton; cytoplasm
Molecular Function:  actin filament binding
Biological Process:  actin filament depolymerization; actin filament fragmentation; actin filament severing; positive regulation of actin filament depolymerization
Reference #:  Q7M0E3 (UniProtKB)
Alt. Names/Synonyms: Actin-depolymerizing factor; ADF; DEST; Destrin; Dstn
Gene Symbols: Dstn
Molecular weight: 18,534 Da
Basal Isoelectric point: 8.19  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene