PKAR2B Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase. Belongs to the cAMP-dependent kinase regulatory chain family. Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible. Note: This description may include information from UniProtKB.

Protein type: Mitochondrial; Protein kinase, regulatory subunit

Chromosomal Location of rat Ortholog: 6q16

Cellular Component: cAMP-dependent protein kinase complex; centrosome; ciliary base; cytoplasm; cytosol; dendrite; dendritic shaft; dendritic spine; glutamatergic synapse; neuronal cell body; perinuclear region of cytoplasm; plasma membrane; postsynapse

Molecular Function: cAMP binding; cAMP-dependent protein kinase inhibitor activity; cAMP-dependent protein kinase regulator activity; kinase activity; protein binding; protein domain specific binding; protein kinase A catalytic subunit binding; protein kinase binding; ubiquitin protein ligase binding

Biological Process: fatty acid metabolic process; learning; modulation of chemical synaptic transmission; negative regulation of cAMP-dependent protein kinase activity; phosphorylation; regulation of protein kinase activity; regulation of protein phosphorylation; response to antipsychotic drug

Reference #: P12369 (UniProtKB)

Alt. Names/Synonyms: cAMP-dependent protein kinase type II-beta regulatory subunit; MGC116401; PKAR2B; Prkar2b; protein kinase, cAMP dependent regulatory, type II beta; RATDNA; Type II beta regulatory subunit of cAMP-dependent protein kinase

Gene Symbols: Prkar2b

Molecular weight: 46,123 Da

Basal Isoelectric point: 4.9 Predict pI for various phosphorylation states

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PKAR2B

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