PKAR2B Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase. Belongs to the cAMP-dependent kinase regulatory chain family. Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible. Note: This description may include information from UniProtKB.
Protein type: Mitochondrial; Protein kinase, regulatory subunit
Chromosomal Location of Human Ortholog: 12|12 A3
Cellular Component:  cAMP-dependent protein kinase complex; centrosome; ciliary base; cytoplasm; cytosol; dendrite; dendritic shaft; dendritic spine; glutamatergic synapse; membrane; membrane raft; neuronal cell body; perinuclear region of cytoplasm; plasma membrane; postsynapse
Molecular Function:  3',5'-cyclic-GMP phosphodiesterase activity; cAMP binding; cAMP-dependent protein kinase inhibitor activity; cAMP-dependent protein kinase regulator activity; nucleotide binding; protein binding; protein domain specific binding; protein kinase A catalytic subunit binding; protein kinase binding; ubiquitin protein ligase binding
Biological Process:  cGMP-mediated signaling; fatty acid metabolic process; learning; modulation of chemical synaptic transmission; negative regulation of cAMP-dependent protein kinase activity; regulation of protein kinase activity; regulation of protein phosphorylation
Reference #:  P31324 (UniProtKB)
Alt. Names/Synonyms: AI451071; AW061005; cAMP-dependent protein kinase type II-beta regulatory subunit; KAP3; OTTMUSP00000018450; OTTMUSP00000018451; Pka; PKAR; PKAR2B; Pkarb2; PKARIIbeta; Prkar2b; protein kinase, cAMP dependent regulatory, type II beta; RII(b; RII(beta)
Gene Symbols: Prkar2b
Molecular weight: 46,167 Da
Basal Isoelectric point: 4.9  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  AMPK Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Hedgehog Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  Parkinson's Disease
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene