PKAR2B a regulatory subunit of cAMP-regulated protein kinase. The inactive form of the enzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules. Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase. Note: This description may include information from UniProtKB.
Protein type: Mitochondrial; Protein kinase, regulatory subunit
Chromosomal Location of Human Ortholog: 12|12 A3
Cellular Component:  cAMP-dependent protein kinase complex; centrosome; ciliary base; cytoplasm; cytosol; dendrite; dendritic shaft; dendritic spine; glutamatergic synapse; membrane; membrane raft; neuronal cell body; perinuclear region of cytoplasm; plasma membrane; postsynapse
Molecular Function:  3',5'-cyclic-GMP phosphodiesterase activity; cAMP binding; cAMP-dependent protein kinase inhibitor activity; cAMP-dependent protein kinase regulator activity; nucleotide binding; protein binding; protein domain specific binding; protein kinase A catalytic subunit binding; protein kinase binding; ubiquitin protein ligase binding
Biological Process:  cGMP-mediated signaling; fatty acid metabolic process; learning; modulation of chemical synaptic transmission; negative regulation of cAMP-dependent protein kinase activity; regulation of protein kinase activity; regulation of protein phosphorylation
Reference #:  P31324 (UniProtKB)
Alt. Names/Synonyms: AI451071; AW061005; cAMP-dependent protein kinase type II-beta regulatory subunit; KAP3; OTTMUSP00000018450; OTTMUSP00000018451; Pkarb2; Prkar2b; protein kinase, cAMP dependent regulatory, type II beta; RII(beta)
Gene Symbols: Prkar2b
Molecular weight: 46,167 Da
Basal Isoelectric point: 4.9  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  AMPK Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Hedgehog Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  Parkinson's Disease
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PKAR2B

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene