GABRG2 Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel. The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer. The alpha1/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity. The alpha2/beta2/gamma2 receptor exhibits synatogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity. Functions also as histamine receptor and mediates cellular responses to histamine. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG2 sub-subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel
Chromosomal Location of Human Ortholog: 5q34
Cellular Component:  axon; cell junction; chloride channel complex; cytoplasmic vesicle membrane; dendrite membrane; GABA-A receptor complex; GABA-ergic synapse; integral component of plasma membrane; plasma membrane; postsynaptic membrane
Molecular Function:  chloride channel activity; GABA-A receptor activity; protein binding
Biological Process:  adult behavior; cellular response to histamine; chloride transmembrane transport; inhibitory synapse assembly; post-embryonic development; synaptic transmission, GABAergic
Disease: Epilepsy, Childhood Absence, Susceptibility To, 2; Epileptic Encephalopathy, Early Infantile, 74
Reference #:  P18507 (UniProtKB)
Alt. Names/Synonyms: CAE2; ECA2; GABA(A) receptor subunit gamma-2; GABRG2; gamma-aminobutyric acid (GABA) A receptor, gamma 2; gamma-aminobutyric acid A receptor, gamma 2; Gamma-aminobutyric acid receptor subunit gamma-2; GBRG2; GEFSP3
Gene Symbols: GABRG2
Molecular weight: 54,162 Da
Basal Isoelectric point: 8.72  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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