GABRG2 Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel. The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer. The alpha1/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity. The alpha2/beta2/gamma2 receptor exhibits synatogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity. Functions also as histamine receptor and mediates cellular responses to histamine. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG2 sub-subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel
Chromosomal Location of mouse Ortholog: 11 A5|11 24.8 cM
Cellular Component:  axon; cell junction; cell projection; chloride channel complex; cytoplasm; cytoplasmic vesicle; dendrite membrane; GABA receptor complex; GABA-A receptor complex; GABA-ergic synapse; glutamatergic synapse; inhibitory synapse; integral component of membrane; integral component of plasma membrane; integral component of postsynaptic specialization membrane; membrane; neuron projection; plasma membrane; postsynapse; postsynaptic membrane; synapse
Molecular Function:  chloride channel activity; GABA-A receptor activity; GABA-gated chloride ion channel activity; inhibitory extracellular ligand-gated ion channel activity; ion channel activity; protein binding; transmembrane signaling receptor activity; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
Biological Process:  adult behavior; cellular response to histamine; chemical synaptic transmission; chloride transmembrane transport; chloride transport; gamma-aminobutyric acid signaling pathway; inhibitory synapse assembly; ion transmembrane transport; ion transport; nervous system process; post-embryonic development; regulation of membrane potential; regulation of postsynaptic membrane potential; signal transduction; synaptic transmission, GABAergic
Reference #:  P22723 (UniProtKB)
Alt. Names/Synonyms: AI851231; BB128510; GAB; GABA(A) receptor subunit gamma-2; GABAA-R; Gabrg; Gabrg-2; Gabrg2; gamm; gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2; gamma-aminobutyric acid (GABA-A) receptor, subunit gamma 2; Gamma-aminobutyric acid receptor subunit gamma-2; GAMMA-AMINOBUTYRIC-ACID RECEPTOR GAMMA-2 SUBUNIT PRECURSOR (GABA(A) RECEPTOR); gamma2; GBRG2
Gene Symbols: Gabrg2
Molecular weight: 55,099 Da
Basal Isoelectric point: 8.88  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene