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NFAT5
Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Mediates the transcriptional response to hypertonicity. Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17. Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3'. Widely expressed, with highest levels in skeletal muscle, brain, heart and peripheral blood leukocytes. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Transcription factor |
| Chromosomal Location of human Ortholog: 16q22.1 |
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Cellular Component:
chromatin; cytosol; nucleoplasm; nucleus; transcription regulator complex
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Molecular Function:
chromatin binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription factor binding
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Biological Process:
calcineurin-NFAT signaling cascade; cellular hyperosmotic response; cellular response to cytokine stimulus; cytokine production; DNA damage response; positive regulation of gene expression; positive regulation of leukocyte adhesion to vascular endothelial cell; positive regulation of NIK/NF-kappaB signaling; positive regulation of transcription by RNA polymerase II; R-loop processing; regulation of calcineurin-NFAT signaling cascade; regulation of transcription by RNA polymerase II; signal transduction; transcription by RNA polymerase II
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Reference #:
O94916
(UniProtKB)
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Alt. Names/Synonyms: glutamine rich protein H65; KIAA0827; NF-AT5; NFAT-like protein 1; NFAT5; NFATL1; NFATZ; nuclear factor of activated T cells 5; Nuclear factor of activated T-cells 5; nuclear factor of activated T-cells 5, tonicity-responsive; OREBP; osmotic response element-binding protein; T cell transcription factor NFAT5; T-cell transcription factor NFAT5; TonE-binding protein; TONEBP; tonicity-responsive enhancer binding protein; Tonicity-responsive enhancer-binding protein
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Gene Symbols: NFAT5
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Molecular weight:
165,763 Da
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Basal Isoelectric point:
5.12
Predict pI for various phosphorylation states
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CST Pathways:
B Cell Receptor Signaling
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T Cell Receptor Signaling
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