R-spondin-4 Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Belongs to the R-spondin family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 2|2 G3
Cellular Component:  extracellular region; extracellular space
Molecular Function:  frizzled binding; heparin binding
Biological Process:  nail development; positive regulation of canonical Wnt signaling pathway; positive regulation of Wnt signaling pathway; response to stimulus; Wnt signaling pathway
Reference #:  Q8BJ73 (UniProtKB)
Alt. Names/Synonyms: A730099F22; A930029K19Rik; Cristin-4; Cysteine-rich and single thrombospondin domain-containing protein 4; mCristin-4; OTTMUSP00000016847; R-spondin family, member 4; R-spondin-4; R-spondin-like protein; Roof plate-specific spondin-4; Rspo4
Gene Symbols: Rspo4
Molecular weight: 25,866 Da
Basal Isoelectric point: 9.49  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene