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RPT2
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC1 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. Belongs to the AAA ATPase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Protease; Proteasome complex |
| Chromosomal Location of mouse Ortholog: 12 E|12 50.43 cM |
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Cellular Component:
cytoplasm; cytosol; membrane; nucleoplasm; nucleus; proteasome accessory complex; proteasome complex; proteasome regulatory particle; proteasome regulatory particle, base subcomplex
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Molecular Function:
ATP binding; ATP hydrolysis activity; nucleotide binding; proteasome-activating activity; TBP-class protein binding
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Biological Process:
negative regulation of neuron death; proteasome-mediated ubiquitin-dependent protein catabolic process; protein catabolic process
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Reference #:
P62192
(UniProtKB)
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Alt. Names/Synonyms: 26S protease regulatory subunit 4; 26S proteasome AAA-ATPase subunit RPT2; 26S proteasome regulatory subunit 4; AI325227; P26; P26s4; protease (prosome, macropain) 26S subunit, ATPase 1; Proteasome 26S subunit ATPase 1; PRS4; Psmc1; RPT2; Rpt2/S4
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Gene Symbols: Psmc1
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Molecular weight:
49,185 Da
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Basal Isoelectric point:
5.87
Predict pI for various phosphorylation states
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