7B2 Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro. Belongs to the 7B2 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Chaperone; Secreted; Secreted, signal peptide
Chromosomal Location of human Ortholog: 15q13.3
Cellular Component:  extracellular region; secretory granule
Molecular Function:  enzyme inhibitor activity; GTP binding; protein binding; unfolded protein binding
Biological Process:  intracellular protein transport; negative regulation of catalytic activity; neuropeptide signaling pathway; peptide hormone processing; regulation of hormone secretion
Reference #:  P05408 (UniProtKB)
Alt. Names/Synonyms: 7B2; C-terminal peptide; N-terminal peptide; Neuroendocrine protein 7B2; P7B2; Pituitary polypeptide; prohormone convertase chaperone; SCG5; Secretogranin V; secretogranin V (7B2 protein); Secretogranin-5; Secretory granule endocrine protein I; secretory granule, neuroendocrine protein 1 (7B2 protein); SGNE1; SgV
Gene Symbols: SCG5
Molecular weight: 23,730 Da
Basal Isoelectric point: 5.62  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein