PIST
Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes. Ubiquitously expressed. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Membrane protein, peripheral |
Chromosomal Location of mouse Ortholog: 10|10 B3 |
Cellular Component:
cell projection; cytoplasm; Golgi apparatus; membrane; plasma membrane; protein-containing complex; synapse; trans-Golgi network transport vesicle
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Molecular Function:
frizzled binding; GTPase regulator activity; identical protein binding; molecular sequestering activity; protein binding; protein homodimerization activity; transmembrane transporter binding
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Biological Process:
autophagy; negative regulation of anion channel activity; negative regulation of protein localization to cell surface; protein transport; spermatid nucleus differentiation
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Reference #:
Q8BH60
(UniProtKB)
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Alt. Names/Synonyms: 2210402P09Rik; AI844555; CAL; FIG; golgi associated PDZ and coiled-coil motif containing; Golgi-associated PDZ and coiled-coil motif-containing protein; GOP; Gopc; GOPC1; PDZ domain-containing protein PIST; PDZ protein interacting specifically with TC10; PIST
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Gene Symbols: Gopc
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Molecular weight:
50,662 Da
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Basal Isoelectric point:
5.83
Predict pI for various phosphorylation states
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