KIRREL Plays a significant role in the normal development and function of the glomerular permeability. Signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1. Belongs to the immunoglobulin superfamily. Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral
Chromosomal Location of mouse Ortholog: 3|3 F1
Cellular Component:  cell projection membrane; cell-cell junction; dendritic shaft; integral component of membrane; membrane; membrane raft; perinuclear region of cytoplasm; plasma membrane
Molecular Function:  myosin binding; protein binding
Biological Process:  cell-cell adhesion; excretion; negative regulation of protein phosphorylation; positive regulation of actin filament polymerization
Reference #:  Q80W68 (UniProtKB)
Alt. Names/Synonyms: 6720469N11Rik; kin of IRRE like (Drosophila); kin of IRRE like 1; Kin of IRRE-like protein 1; Kin of irregular chiasm-like protein 1; Kir; KIRR1; kirre like nephrin family adhesion molecule 1; Kirrel; Kirrel1; Nep; Neph1; nephrin 1; Nephrin-like protein 1
Gene Symbols: Kirrel
Molecular weight: 87,176 Da
Basal Isoelectric point: 5.65  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene