LIMD1 Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG- dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1- responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. Belongs to the zyxin/ajuba family. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Tumor suppressor
Chromosomal Location of Human Ortholog: 9 F4|9 74.0 cM
Cellular Component:  adherens junction; cell junction; cytoplasm; focal adhesion; intercellular junction; nucleus; P-body; plasma membrane; RISC complex; transcription factor complex
Molecular Function:  metal ion binding; protein binding; transcription corepressor activity
Biological Process:  cell migration; cytoplasmic mRNA processing body assembly; cytoskeleton organization; miRNA-mediated gene silencing; negative regulation of canonical Wnt signaling pathway; negative regulation of osteoblast differentiation; negative regulation of transcription, DNA-dependent; osteoblast development; phosphorylation; positive regulation of gene silencing by miRNA; regulation of cell shape; regulation of transcription, DNA-templated; response to hypoxia; RNA-mediated gene silencing; transcription, DNA-dependent
Reference #:  Q9QXD8 (UniProtKB)
Alt. Names/Synonyms: AW822033; D9Ertd192e; LIM domain-containing protein 1; LIM domains containing 1; Limd1
Gene Symbols: Limd1
Molecular weight: 71,422 Da
Basal Isoelectric point: 5.88  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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LIMD1

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene