latrophilin 1 Calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis. Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 8|8 C2
Cellular Component:  axon; cell junction; cell projection; glutamatergic synapse; growth cone; integral component of membrane; integral component of plasma membrane; integral component of presynaptic membrane; membrane; neuron projection; plasma membrane; postsynaptic density; presynaptic membrane; synapse
Molecular Function:  carbohydrate binding; cell adhesion molecule binding; G protein-coupled receptor activity; latrotoxin receptor activity; toxic substance binding; transmembrane signaling receptor activity
Biological Process:  adenylate cyclase-activating G protein-coupled receptor signaling pathway; calcium-mediated signaling using intracellular calcium source; cell surface receptor signaling pathway; G protein-coupled receptor signaling pathway; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; positive regulation of synapse assembly; positive regulation of synapse maturation; signal transduction
Reference #:  Q80TR1 (UniProtKB)
Alt. Names/Synonyms: 2900070I05Rik; Adgrl1; Adhesion G protein-coupled receptor L1; AGRL1; AI182398; Calcium-independent alpha-latrotoxin receptor 1; CIRL-1; CLIBA; G protein coupled receptor Lec2; Kiaa0821; latrophilin 1; Latrophilin-1; Lec; Lec2; Lectomedin-2; Lphn1; MGC109680; mKIAA0821
Gene Symbols: Lphn1
Molecular weight: 161,686 Da
Basal Isoelectric point: 6.07  Predict pI for various phosphorylation states
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latrophilin 1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene