Erbin Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state. Inhibits NOD2-dependent NF-kappa-B signaling and proinflammatory cytokine secretion. Belongs to the LAP (LRR and PDZ) protein family. Highly expressed in brain, heart, kidney, muscle and stomach, followed by liver, spleen and intestine. 9 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion
Chromosomal Location of mouse Ortholog: 13|13 D1
Cellular Component:  anchoring junction; basolateral plasma membrane; cell junction; cytoplasm; glutamatergic synapse; hemidesmosome; membrane; neuromuscular junction; nuclear speck; nucleus; plasma membrane; postsynapse; postsynaptic specialization
Molecular Function:  protein binding; signaling receptor binding
Biological Process:  cellular response to tumor necrosis factor; negative regulation of monocyte chemotactic protein-1 production; negative regulation of NF-kappaB transcription factor activity; negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway; protein targeting; regulation of postsynaptic membrane neurotransmitter receptor levels; response to lipopolysaccharide; response to muramyl dipeptide; signal transduction
Reference #:  Q80TH2 (UniProtKB)
Alt. Names/Synonyms: 1700028E05Rik; Densin-180-like protein; Erbb; Erbb2 interacting protein; Erbb2-interacting protein; Erbb2ip; Erbin; Kiaa1225; Lap2; mKIAA1225; Protein LAP2
Gene Symbols: Erbin
Molecular weight: 157,248 Da
Basal Isoelectric point: 5.46  Predict pI for various phosphorylation states
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Erbin

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene