endofin May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes. Widely expressed. Highly expressed in kidney, placenta and lung. Expressed at intermediate level in heart, brain, skeletal muscle, spleen and liver. Weakly expressed in colon, thymus and peripheral blood lymphocytes. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Lipid-binding
Chromosomal Location of Human Ortholog: 13|13 C3
Cellular Component:  cytoplasm; cytosol; early endosome; early endosome membrane; endosome; intracellular membrane-bounded organelle; membrane
Molecular Function:  1-phosphatidylinositol binding; metal ion binding; phosphatidylinositol-3,4,5-trisphosphate binding
Biological Process:  endosomal transport; protein targeting to lysosome
Reference #:  Q80U44 (UniProtKB)
Alt. Names/Synonyms: AI035632; B130024H06Rik; B130031L15; Endofin; Endosomal-associated FYVE domain protein; Kiaa0305; mKIAA0305; OTTMUSP00000029589; ZFY16; Zfyve16; Zinc finger FYVE domain-containing protein 16; zinc finger, FYVE domain containing 16
Gene Symbols: Zfyve16
Molecular weight: 166,670 Da
Basal Isoelectric point: 4.66  Predict pI for various phosphorylation states
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endofin

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene