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En-2
Belongs to the engrailed homeobox family. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Transcription factor |
| Chromosomal Location of human Ortholog: 7q36.3 |
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Cellular Component:
chromatin; fibrillar center; nucleolus; nucleoplasm; nucleus
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Molecular Function:
DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific double-stranded DNA binding
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Biological Process:
dopaminergic neuron differentiation; embryonic brain development; hindbrain development; midbrain development; negative regulation of neuron apoptotic process; neuron development; neuron differentiation; positive regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II
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Disease: Autism, Susceptibility To, 10
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Reference #:
P19622
(UniProtKB)
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Alt. Names/Synonyms: En-2; EN2; engrailed homeobox 2; engrailed homolog 2; engrailed-2; HME2; Homeobox protein en-2; Homeobox protein engrailed-2; Hu-En-2
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Gene Symbols: EN2
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Molecular weight:
34,211 Da
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Basal Isoelectric point:
9.49
Predict pI for various phosphorylation states
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