dynactin 2 Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development. Belongs to the dynactin subunit 2 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Cytoskeletal; Microtubule-binding; Motility/polarity/chemotaxis; Motor
Chromosomal Location of Human Ortholog: 10 D3|10 74.5 cM
Cellular Component:  centrosome; cytoplasm; cytoskeleton; cytosol; dynactin complex; dynein complex; growth cone; kinetochore; membrane; microtubule; vesicle
Molecular Function:  identical protein binding; motor activity; protein binding; protein kinase binding; spectrin binding
Biological Process:  cell proliferation; melanosome transport; microtubule-based process; mitotic cell cycle; mitotic spindle organization; protein localization to centrosome
Reference #:  Q99KJ8 (UniProtKB)
Alt. Names/Synonyms: 2310042E05Rik; 50 kDa dynein-associated polypeptide; C130077D06Rik; C87049; DCTN-5; DCTN-50; Dctn2; dynactin 2; Dynactin complex 50 kDa subunit; Dynactin subunit 2; GMP23-48K; Growth cone membrane protein 23-48K; p50; p50 dynamitin; RBP; RBP50
Gene Symbols: Dctn2
Molecular weight: 44,117 Da
Basal Isoelectric point: 5.14  Predict pI for various phosphorylation states
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dynactin 2

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene