RCC1 Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis. Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis. Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; GEF; GEF, Ras
Chromosomal Location of Human Ortholog: 1p35.3
Cellular Component:  chromatin; condensed nuclear chromosome; cytoplasm; nuclear chromatin; nuclear membrane; nucleoplasm; nucleus; protein-containing complex
Molecular Function:  chromatin binding; histone binding; nucleosomal DNA binding; nucleosome binding; protein binding; protein heterodimerization activity; Ran GTPase binding; Ran guanyl-nucleotide exchange factor activity; sulfate binding
Biological Process:  cell division; chromosome segregation; G1/S transition of mitotic cell cycle; mitotic spindle organization; protein heterotetramerization; regulation of mitotic nuclear division; spindle assembly; viral process
Reference #:  P18754 (UniProtKB)
Alt. Names/Synonyms: Cell cycle regulatory protein; CHC1; chromosome condensation 1; Chromosome condensation protein 1; guanine nucleotide-releasing protein; RCC1; RCC1-I; Regulator of chromosome condensation; regulator of chromosome condensation 1; SNHG3-RCC1; SNHG3-RCC1 readthrough
Gene Symbols: RCC1
Molecular weight: 44,969 Da
Basal Isoelectric point: 7.18  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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