RYR1 Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis. Belongs to the ryanodine receptor (TC 1.A.3.1) family. RYR1 subfamily. Skeletal muscle and brain (cerebellum and hippocampus). 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel
Chromosomal Location of Human Ortholog: 7 B1|7 16.94 cM
Cellular Component:  calcium channel complex; cell cortex; cytoplasm; cytoplasmic vesicle membrane; extrinsic component of cytoplasmic side of plasma membrane; I band; integral component of membrane; junctional membrane complex; membrane; plasma membrane; protein-containing complex; sarcolemma; sarcoplasmic reticulum; sarcoplasmic reticulum membrane; smooth endoplasmic reticulum; T-tubule; terminal cisterna; Z disc
Molecular Function:  ATP binding; calcium channel activity; calcium ion binding; calcium-induced calcium release activity; calcium-release channel activity; calmodulin binding; enzyme binding; ion channel activity; metal ion binding; nucleotide binding; protease binding; protein binding; ryanodine-sensitive calcium-release channel activity; voltage-gated calcium channel activity
Biological Process:  calcium ion transmembrane transport; calcium ion transport; cellular calcium ion homeostasis; cellular response to ATP; cellular response to caffeine; ion transport; multicellular organism development; muscle contraction; ossification involved in bone maturation; outflow tract morphogenesis; regulation of cytosolic calcium ion concentration; regulation of muscle contraction; release of sequestered calcium ion into cytosol; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; response to caffeine; response to hypoxia; sarcoplasmic reticulum calcium ion transport; skeletal muscle fiber development; skin development; transmembrane transport
Reference #:  E9PZQ0 (UniProtKB)
Alt. Names/Synonyms: AI528790; calcium release channel; Ryanodine receptor; Ryanodine receptor 1; ryanodine receptor 1, skeletal muscle; Ryr; Ryr1; skeletal muscle ryanodine receptor; skrr
Gene Symbols: Ryr1
Molecular weight: 565,039 Da
Basal Isoelectric point: 5.16  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene