SLC4A7 Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Regulates intracellular pH and may play a role in bicarbonate salvage in secretory epithelia. May also have an associated sodium channel activity. Belongs to the anion exchanger (TC 2.A.31) family. Highly expressed in testis and spleen. Also expressed in retina, colon, small intestine, ovary, thymus, prostate, muscle, heart and kidney. Isoform 1 is expressed in skeletal muscle and heart muscle. 14 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 3p24.1
Cellular Component:  apical plasma membrane; basolateral plasma membrane; cytoplasmic vesicle; integral component of membrane; plasma membrane; stereocilium; synapse
Molecular Function:  inorganic anion exchanger activity; sodium:bicarbonate symporter activity
Biological Process:  anion transmembrane transport; bicarbonate transport; inorganic anion transport; sodium ion transport
Reference #:  Q9Y6M7 (UniProtKB)
Alt. Names/Synonyms: Bicarbonate transporter; BT; DKFZp686H168; Electroneutral Na/HCO(3) cotransporter; NBC2; NBC2B; NBC3; NBCn1; S4A7; SBC2; SLC4A6; SLC4A7; Sodium bicarbonate cotransporter 2; Sodium bicarbonate cotransporter 2b; Sodium bicarbonate cotransporter 3; Solute carrier family 4 member 7; solute carrier family 4, sodium bicarbonate cotransporter, member 7
Gene Symbols: SLC4A7
Molecular weight: 136,044 Da
Basal Isoelectric point: 6.26  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB