Trap150 Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-ARNTL/BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes. Belongs to the BCLAF1/THRAP3 family. Ubiquitous. Note: This description may include information from UniProtKB.
Protein type: RNA-binding; Transcription, coactivator/corepressor
Chromosomal Location of human Ortholog: 1p34.3
Cellular Component:  mediator complex; nuclear speck; nucleoplasm; nucleus
Molecular Function:  ATP binding; nuclear receptor transcription coactivator activity; phosphoprotein binding; protein binding; RNA polymerase II distal enhancer sequence-specific DNA binding; thyroid hormone receptor binding; transcription coactivator activity; transcription coregulator activity; vitamin D receptor binding
Biological Process:  circadian rhythm; mRNA processing; mRNA stabilization; nuclear-transcribed mRNA catabolic process; positive regulation of circadian rhythm; positive regulation of mRNA splicing, via spliceosome; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; regulation of alternative mRNA splicing, via spliceosome; RNA splicing; transcription initiation from RNA polymerase II promoter
Reference #:  Q9Y2W1 (UniProtKB)
Alt. Names/Synonyms: BCLAF1 and THRAP3 family member 2; BCLAF2; FLJ22082; MGC133082; MGC133083; THRAP3; thyroid hormone receptor associated protein 3; Thyroid hormone receptor-associated protein 3; Thyroid hormone receptor-associated protein complex 150 kDa component; thyroid hormone receptor-associated protein, 150 kDa subunit; TR-associated protein, 150-kDa; TR150; TRAP150
Gene Symbols: THRAP3
Molecular weight: 108,666 Da
Basal Isoelectric point: 10.16  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene