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R-spondin-4
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Belongs to the R-spondin family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell development/differentiation; Secreted; Secreted, signal peptide |
| Chromosomal Location of human Ortholog: 20p13 |
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Cellular Component:
extracellular region
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Molecular Function:
heparin binding; protein binding
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Biological Process:
nail development; positive regulation of Wnt signaling pathway; Wnt signaling pathway
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Disease: Nail Disorder, Nonsyndromic Congenital, 4
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Reference #:
Q2I0M5
(UniProtKB)
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Alt. Names/Synonyms: C20orf182; CRISTIN4; FLJ16018; hRspo4; R-spondin 4; R-spondin family, member 4; R-spondin-4; Roof plate-specific spondin-4; RSPO4
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Gene Symbols: RSPO4
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Molecular weight:
26,171 Da
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Basal Isoelectric point:
9.38
Predict pI for various phosphorylation states
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