DENND4C Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, Rab; Membrane protein, integral
Chromosomal Location of Human Ortholog: 9p22.1
Cellular Component:  cytoplasmic vesicle membrane; cytosol; insulin-responsive compartment; plasma membrane; retromer complex
Molecular Function:  Rab guanyl-nucleotide exchange factor activity
Biological Process:  cellular response to insulin stimulus; protein localization to plasma membrane; protein transport
Reference #:  Q5VZ89 (UniProtKB)
Alt. Names/Synonyms: bA513M16.3; C9orf55; C9orf55B; DEN4C; DENN domain-containing protein 4C; DENN/MADD domain containing 4C; DENND4C; DKFZp686I09113; FLJ20686
Gene Symbols: DENND4C
Molecular weight: 212,711 Da
Basal Isoelectric point: 6.39  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene