AP1AR Necessary for adaptor protein complex 1 (AP-1)-dependent transport between the trans-Golgi network and endosomes. Regulates the membrane association of AP1G1/gamma1-adaptin, one of the subunits of the AP-1 adaptor complex. The direct interaction with AP1G1/gamma1-adaptin attenuates the release of the AP-1 complex from membranes. Regulates endosomal membrane traffic via association with AP-1 and KIF5B thus linking kinesin-based plus-end-directed microtubular transport to AP-1-dependent membrane traffic. May act as effector of AP-1 in calcium-induced endo-lysosome secretion. Inhibits Arp2/3 complex function; negatively regulates cell spreading, size and motility via intracellular sequestration of the Arp2/3 complex. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Vesicle
Chromosomal Location of Human Ortholog: 4q25
Cellular Component:  cytosol; early endosome; Golgi apparatus; late endosome; transport vesicle
Molecular Function:  AP-1 adaptor complex binding; kinesin binding
Biological Process:  cellular protein localization; negative regulation of cell motility; negative regulation of receptor recycling; negative regulation of substrate adhesion-dependent cell spreading; protein transport; regulation of Arp2/3 complex-mediated actin nucleation; vesicle targeting, trans-Golgi to endosome
Reference #:  Q63HQ0 (UniProtKB)
Alt. Names/Synonyms: 2c18; Adapter-related protein complex 1-associated regulatory protein; adaptor related protein complex 1 associated regulatory protein; adaptor-related protein complex 1 associated regulatory protein; Adaptor-related protein complex 1-associated regulatory protein; AP-1 complex-associated regulatory protein; AP1AR; C4orf16; Gadkin; Gamma-1-adaptin brefeldin A resistance protein; Gamma-A1-adaptin and kinesin interactor; Gamma-BAR; gamma1-adaptin brefeldin A resistance protein, gamma-BAR; GBAR; PRO0971
Gene Symbols: AP1AR
Molecular weight: 34,280 Da
Basal Isoelectric point: 4.79  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein