RAB11FIP5 Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis. Detected at low levels in heart, brain, placenta, lung, liver, adipocytes, kidney, spleen, skeletal muscle and pancreas. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 2p13.2
Cellular Component:  early endosome; early endosome membrane; Golgi apparatus; Golgi membrane; intracellular membrane-bounded organelle; microtubule organizing center; mitochondrial outer membrane; recycling endosome; recycling endosome membrane; secretory granule; transport vesicle membrane
Molecular Function:  gamma-tubulin binding; protein binding
Biological Process:  cellular response to acidic pH; insulin secretion involved in cellular response to glucose stimulus; negative regulation of adiponectin secretion; regulated exocytosis; regulation of protein localization to cell surface
Reference #:  Q9BXF6 (UniProtKB)
Alt. Names/Synonyms: DKFZp434H018; Gaf-1; GAF1; Gamma-SNAP-associated factor 1; KIAA0857; Phosphoprotein pp75; pp75; RAB11 family interacting protein 5; RAB11 family interacting protein 5 (class I); Rab11 family-interacting protein 5; Rab11-FIP5; Rab11-interacting protein Rip11; RAB11FIP5; RFIP5; RIP11
Gene Symbols: RAB11FIP5
Molecular weight: 70,415 Da
Basal Isoelectric point: 9.28  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene