FNBP1 May act as a link between RND2 signaling and regulation of the actin cytoskeleton. Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL. Belongs to the FNBP1 family. Very highly expressed in the epithelial cells of the gastrointestinal tract, respiratory, reproductive and urinary systems. Also highly expressed in brown adipose tissue, cardiomyocytes, enteric ganglia and glucagon producing cells of the pancreas. Expressed in germ cells of the testis and all regions of the brain. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Vesicle
Chromosomal Location of human Ortholog: 9q34.11
Cellular Component:  cell cortex; clathrin-coated pit; cytoplasmic vesicle; cytoskeleton; cytosol; lysosome; plasma membrane
Molecular Function:  identical protein binding; lipid binding; protein binding
Biological Process:  endocytosis; membrane organization
Reference #:  Q96RU3 (UniProtKB)
Alt. Names/Synonyms: FBP17; FNBP1; formin binding protein 1; Formin-binding protein 1; Formin-binding protein 17; hFBP17; KIAA0554; MGC126804
Gene Symbols: FNBP1
Molecular weight: 71,307 Da
Basal Isoelectric point: 5.53  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene