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USP6NL
Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex. Widely expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: GAP; GAP, Rab; Ubiquitin-specific protease |
| Chromosomal Location of human Ortholog: 10p14 |
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Cellular Component:
cytoplasmic vesicle; cytosol; plasma membrane; trans-Golgi network membrane
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Molecular Function:
GTPase activator activity; small GTPase binding
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Biological Process:
activation of GTPase activity; Golgi organization; plasma membrane to endosome transport; positive regulation of GTPase activity; regulation of cilium assembly; regulation of Golgi organization; retrograde transport, plasma membrane to Golgi; virion assembly
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Reference #:
Q92738
(UniProtKB)
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Alt. Names/Synonyms: KIAA0019; related to the N terminus of tre; Related to the N-terminus of tre; RN-tre; RNTRE; TRE2NL; US6NL; USP6 N-terminal like; USP6 N-terminal-like protein; USP6NL; USP6NL-IT1
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Gene Symbols: USP6NL
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Molecular weight:
94,104 Da
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Basal Isoelectric point:
9.1
Predict pI for various phosphorylation states
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